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Models

• Cell Line Derived Xenograft
• HSC and PBMC Humanized
• Human Target Knock-In ( HuGEMM^TM )
• Patient-Derived Xenograft ( HuPrime^TM )
• Syngeneic
• Tumor Homograft ( MuPrime^TM )

Inflammation

In Vivo Models

• Inflammatory Bowel Disease (IBD)
• Rheumatoid Arthritis (RA)

Biomarker Services

• Flow Cytometry Platform
• Histology and Digital Pathology Platform

CVMD

Home

Cardiovascular Disease

• NHP
• Rodent

Diabetes

• NHP
• Rodent

NAFLD/NASH

• NHP
• MS-NASH (FATZO)

Obesity

• NHP
• Rodent

Renal Disease

• NHP
• Rodent

Safety/Toxicology

• Non-GLP Toxicology
• Safety Pharmacology

Oncology

In Vivo Services

• Breast Cancer Preclinical Models
• Cell Line Derived Xenograft Models
• Custom Tumor Model Development
• Immuno-Oncology Models
• MuScreen
• Orthotopic and Bioluminescent Models
• Patient-Derived Xenograft Models (HuPrime/HuKemia)
• Prostate Cancer Preclinical Models
• Radiation Therapy
• Syngeneic Tumor Models

In Vitro Services

• Cell Based Screening
  • CrownSyn
• Cell Line Panels
• Flow Cytometry Platform
• Immuno-Oncology
• OmniScreen Cell Based Screening Service
• Organoids
• PDX-Derived Cell Lines

Ex Vivo Services

• 3D Assays
• Tumor Microarrays

Immuno-Oncology

• CAR-T Cell Therapy Models
  • Cell Line Derived Xenografts Targeting CD19
  • PDX
• Humanized Models
  • Hematopoietic Stem Cell (HSC)-PDX
  • MiXeno
• Human Target Knock-In Models
  • HuGEMM
  • HuCELL
• Murine Immunity Models and Services
  • Tumor Homograft Models
  • Syngeneic tumor models
  • MuScreen

Oncology

Translational Oncology

• 1+1 Mouse Trial
• Biomarkers of Response (HuMark)
• Mouse Clinical Trials (HuTrial)
• Signatures of Response (HuSignature)

Biomarker Services

• Cytokine and Chemokine Profiling Platform
• Flow Cytometry Platform
• Histology and Digital Pathology Platform

Pharmacology and Bioanalytical Services

• ADME & Physicochem
• Bioanalysis Studies
• FACS Platform
• In Vivo PK/PD
• NHP Immuno-Safety
• Structural Biology
• Target Validation

Oncology Databases

• HuBase
• MuBase
• OncoExpress
• XenoBase