Publications

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Our 3D cell culture platforms described in detail, including the 3D tumor growth assay (3D TGA) using PDX-derived cells.

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Oncology drug development has an overly high attrition rate for novel agents in late-phase clinical trials, which needs to be improved to enhance the efficiency and cost-effectiveness of developing new therapies. Precision profiling using Patient-Derived Xenografts (PDX), the most predictive...

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  • Syngeneic models, showcasing our ever expanding syngeneic collection, FACS analysis, and checkpoint inhibitor benchmarking
  • MuScreen™ CrownBio’s large-scale, staggered screening platform to fast-track the in vivo screening of immunotherapy compounds
  • MuPrime™ - allografts of spontaneous murine...

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  • Evaluating Cell Line Derived Xenograft and Patient-Derived Xenograft (PDX) models in humanized mice, including immune memory response
  • MiXeno™ models featuring transient human immunity in mice, providing a simple alternative to the full stem cell reconstitution approach
  • HuGEMM™ and HuCELL™, our...

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Our PDX collection key features are summarized in our HuPrime® FactSheet

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Fusion oncogenic events are important targets for oncology research, potentially providing ‘druggable’ targets for subsets of cancer patients. We currently provide FactSheets on:

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CrownBio also provides details on our comprehensive Non-GLP Toxicology and Safety Pharmacology assessments in NHPs and rodents

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CrownBio provides a comprehensive In Vivo Immunotherapy Translational Technology Platform, and our FactSheets bring you detailed information across a range of our immuno- oncology services.

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